When SSRIs Stop Working WisdomCard™

Our Guides and Physician Review team have organized the Top 10 Health Resources on When SSRIs Stop Working and compiled helpful research notes below.

  1. Mayo Clinic: Antidepressants: Can they lose effectiveness over time? mayoclinic.com - Antidepressants: Can they lose effectiveness over time?
  2. Wikipedia: Antidepressant - Medication Failure en.wikipedia.org - Antidepressant - Medication Failure
  3. WebMD: Other Disadvantages webmd.com - Other Disadvantages
  4. New York Times (via The Good Drug Guide): The Pitfalls in a Pill biopsychiatry.com - The Pitfalls in a Pill
  5. Dr. Bob Home Page: when ssri's stop working, what's next? dr-bob.org - when ssri's stop working, what's next?
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Research Notes on When SSRIs Stop Working


SSRIs are antidepressants that can be prescribed for people with bipolar disorder or people suffering from depression. Sometimes an antidepressant may cease to be effective for a particular patient.1 Doctors are still unsure of what causes this tolerance.2

Fast Facts

  • Possible solutions may include an increase in dosage or switching medications.1
  • Antidepressants may lose effectiveness in up to 20% of patients.2
  • Factors that may influence this are aging, other medical conditions, interactions with new medications, or a worsening of depression.2
  • Consult a psychiatrist to explore all possible causes if your medication seems to lose effectiveness.2

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Research Notes References

  1. ↑ 1.0 1.1 Wikipedia: Antidepressant – Medication Failure
  2. ↑ 2.0 2.1 2.2 2.3 Mayo Clinic: Antidepressants: Can They Lose Effectiveness Over Time?

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