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Thyroxine-Binding Globulin

Try also: Depakote; Estrogen; and Fatigue

Research Notes on Thyroxine-Binding Globulin


Thyroxine-binding globulin (TBG) binds Thyroid hormone in circulation. It is one of three proteins (along with transthyretin and albumin) responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3’-triiodothyronine (T3) in the bloodstream. Of these three proteins, TBG has the highest affinity for T4 and T3, but is present in the lowest concentration. Despite its low concentration, TBG carries the majority of T4 in serum. ...read more at Wikipedia

Fast Facts:

  • TBG's are normally higher when tested on newborns.1
  • Most of the TGB is attached to both T3 and T2 with less than 1% being unattached.2
  • Drugs that may increase TBG test results: estrogen, heroin, methadone and phenothiazines.1
  • Drugs that may decrease TBG test results: depakote, phenytoin, male hormones and prednisone.1

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Research Notes References

  1. ↑ 1.0 1.1 1.2 A.D.A.M. (via MedlinePlus): Serum TBG Level
  2. ↑ Healthwise (via Yahoo Health): Thyroid Hormone Tests

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About this WisdomCard

  • Contributor: Carolyn DeLucas
  • Reviewer: Tara
  • Supervised by: The OrganizedWisdom Physician Review Team
  • Redirects:Thyroxine-binding globulin, TGB, Tgb, Thiroxine binding globulin, Thiroxine Binding Globulin, Thyroxine-Binding Globulin Test, Test of Thyroxine-Binding Globulin, Thyroxine-Binding Globulin Signs, Signs of Thyroxine-Binding Globulin, Thyroxine-Binding Globulin Diagnosis, Diagnosis of Thyroxine-Binding Globulin, Thyroxine-Binding Globulin Symptoms, Symptoms of Thyroxine-Binding Globulin
  • Last update: Nov. 10, 2008

Each WisdomCard is handcrafted by our team of physician-guided health advocates. Our goal is to make it easy for you to find the most useful health resources for any health topic by filtering out spam and bad links.