Streptozotocin WisdomCard™

Our Guides and Physician Review team have organized the Top 10 Health Resources on Streptozotocin and compiled helpful research notes below.

  1. Wikipedia: Streptozotocin (Streptozocin, STZ, Zanosar) en.wikipedia.org - Streptozotocin (Streptozocin, STZ, Zanosar)
  2. National Academy of Sciences: Studies of Streptozotocin-Induced Insulitis and Diabetes pnas.org - Studies of Streptozotocin-Induced Insulitis and Diabetes
  3. Healthwise (via Sutter Health): Streptozocin sutterhealth.org - Streptozocin
  4. Cancer Consultants: Zanosar® Superior to Doxorubicin for Advanced Carcinoid Tumors professional.cancerconsultants.com - Zanosar® Superior to Doxorubicin for Advanced Carcinoid Tumors
  5. OncoLink: Streptozocin Other Name: Zanosar oncolink.com - Streptozocin Other Name: Zanosar
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Research Notes on Streptozotocin

Streptozotocin is a chemical that occurs naturally and is used to treat spreading cancer of the pancreatic islet cells. It is not very successful in curing the cancer. Therefore it is primarily used on people whose cancer cannot be removed by surgery.1 One side effect of streptozotocin is that it is destructive to insulin producing cells.2 Streptozotocin injected into mice has been shown to destroy the beta cells in the pancreas and thus inducing pancreatic insulitis which leads to diabetes mellitus.3

Fast Facts:

  • Used in animals to cause type 1 diabetes for research purposes.1
  • Is toxic to the beta cells thus causing damage to the DNA.1
  • Streptozotocin was introduced in the 1950's as an antibiotic.1
  • Streptozotocin is classified as a carcinogen.2

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Research Notes References

  1. ↑ 1.0 1.1 1.2 1.3 Wikipedia: Streptozotocin (Streptozocin, STZ, Zanosar)
  2. ↑ 2.0 2.1 The American Heritage Dictionary (via Bartleby): Streptozotocin
  3. ↑ Pubmed: Streptozotocin-Induced Pancreatic Insulitis: New Model of Diabetes Mellitus.

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