PAPA Syndrome WisdomCard

Our Guides and Physician Review team have organized the Top 10 Health Resources on PAPA Syndrome and compiled helpful research notes below.


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Research Notes on PAPA Syndrome


PAPA syndrome is a genetic disorder that consists of pyogenic arthritis, pyoderma gangrenosum, and acne. Children have a 50% chance of inheriting PAPA syndrome from an affected parent. The disorder begins with arthritis at an early age. The changes to the skin usually occur during puberty.1

Fast Facts:

  • A mutation of genes on chromosome 15q is the cause of PAPA syndrome.2
  • The acne associated with PAPA syndrome usually causes scarring.2
  • PAPA syndrome is also referred to as familial recurrent arthritis.3

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Research Notes References

  1. New Zealand Dermatological Society: PAPA Syndrome
  2. 2.0 2.1 Merck Manuals: Hereditary Periodic Fever Syndromes: PAPA Syndrome
  3. GeneDx: Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome

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