Naproxen Drug Interactions WisdomCard

Our Guides and Physician Review team have organized the Top 10 Health Resources on Naproxen Drug Interactions and compiled helpful research notes below.


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Research Notes on Naproxen Drug Interactions


Naproxen can have serious negative interactions with various over-the-counter and prescription medications, including: lithium, aspirin, cholestyramine, beta blockers, and other NSAID pain relievers. An increased risk of bleeding, stomach ulcers, and an elevated level of naproxen in the blood may occur when some medications are used with naproxen. Before using naproxen, be certain that your physician is aware of any and all over-the-counter, prescription, and herbal medications you may be taking.1

Fast Facts:

  • Methotrexate, diuretics, steroids, and blood thinners can also negatively interact with naproxen.2
  • Using antidepressants while using naproxen can increase your risk of bleeding or bruising easily.2
  • Your physician may still recommend the use of naproxen if you are using one of these medications, however, your dosage may be adjusted.2


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Research Notes References

  1. eMedTV: Naproxen Drug Interactions
  2. 2.0 2.1 2.2 Cerner Multum (via Drugs.com): What Other Drugs Will Affect Naproxen?

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