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GuideWisdom™

This WisdomCard managed by: Chris Miller

Miglustat is a medication utilized to treat Gaucher disease in patients who cannot be treated with enzyme replacement therapy using imiglucerase.¹ Type 1 Gaucher is inherited from both parents, and people affected by the disease are missing an enzyme that breaks down a chemical called glucosylceramide.²

Fast Facts:

• -- Sold as the generic for the brand Zavesca.
• -- Works by preventing the body from making glucosylceramide.²
• -- Side effects include bleeding gums, blood in the urine or stool, and numbness or tingling.²
• -- Miglustat has been tested for the treatment of Niemann Pick disease.

5 Great Resources on Miglustat

• Wikipedia: Miglustat
• Micromedex (via Mayo Clinic): Miglustat (Oral Route)
• American Society of Health-System Pharmacists (via MedlinePlus): Miglustat
• RxList: Zavesca (Miglustat) Capsules
• Drug Digest: Miglustat Capsules

5 Latest Headlines on Miglustat

• More Miglustat News from Medworm

What is Miglustat?

• Unified Medical Language System (via DiseasesDictionary): Miglustat Definition
• Cerner Multum (via MedHelp): What is Miglustat?
• MediResource (via MedBroadcast): How Does This Medication Work? What Will It Do For Me?

What are the Uses for Miglustat?

• Wolters Kluwer Health (via Drugs.com): What Miglustat is Used For
• McKesson Corporation (via RealAge): What is This Medicine Used For?
• GoldBamboo: Miglustat Uses

What are the Side Effects, Interactions and Precautions for Miglustat?

• Lexi-Comp (via Merck Manuals): Adverse Reactions
• MediResource (via MedBroadcast): What Side Effects are Possible With This Medication?
• RxList: Zavesca Side Effects & Drug Interactions

What are the Alternatives to Miglustat?

• WebMD (via eMedicine): Gaucher Disease Treatment
• Genzyme: Gaucher Disease - Treatment
• Mayo Clinic: Gaucher's Disease - Treatment and Drugs
• National Institute of Neurological Disorders and Stroke: Gaucher Disease Is There Treatment?

Wisdom, Blogs and Message Boards about Miglustat

• Google Groups: Sci.Med Fourm - HELP! GM1 Gangliosidosis - Cured With Miglustat (Zavesca)
• Google Groups: International School Johor Forum - The Drug Buying Time for Children
• Yahoo Message Boards: EMEA Approves OGS Drug Rejected by FDA

Clinical Trials for Miglustat

• ClinicalTrials.gov: List of Miglustat Clinical Trials

Controversy and Lawsuits about Miglustat

• Medical News Today: Effect Of Miglustat On Bone Disease In Adult Type 1 Gaucher Disease (GD1): Results Of Apooleda Pooled Analysis (Sept 5, 2007)
• Pharmaceutical Business Review: Actelion Starts Miglustat Phase II Study for Cystic Fibrosis (Oct 2, 2007)
• PrimeNewswire: Actelion Ltd: Miglustat (Zavesca) Receives Negative Opinion From the European Committee For Medicinal Products For Human Use For Extension of Indication For Niemann Pick Type C (Oct 19, 2007)

Abuse of Miglustat

• American Society of Health-System Pharmacists (via Prevention.com): In Case of Overdose
• National Library of Medicine & Centers for Disease Control and Prevention (via Healthocrotes): Miglustat Side Effects
• Healthwise (via Yahoo Health): What Happens if I Overdose?

Scientific and Medical Journal Articles on Miglustat

• Google Scholar: Articles About Miglustat
• PubMed Central: Miglustat Articles

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GuideWisdom and Fast Facts References

1. ↑ Wikipedia: Miglustat
2. ↑ ^{2.0 2.1 2.2} Micromedex (via Mayo Clinic): Miglustat (Oral Route)

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