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GuideWisdom™

This WisdomCard managed by: Chris Miller

Methylnaltrexone (MTNX, tradename Relistor) is one of the newer agents of peripherally-acting μ-opioid antagonists that act to reverse some of the side effects of opioid drugs such as constipation without affecting analgesia or precipitating withdrawals. Because it contains a permanently charged tetravalent nitrogen atom, it cannot cross the blood-brain barrier, and so has antagonist effects throughout the body, counteracting effects such as itching and constipation, but without affecting opioid effects in the brain such as analgesia. ...read more at Wikipedia

Fast Facts:

• -- Methylnaltrexone is used when other medications have failed.¹
• -- The trade name for Methylnaltrexone is Relistor.²
• -- The use of Methylnaltrexone was approved by the FDA on April 24, 2008.²

5 Great Resources on Methylnaltrexone

• RxList: Relistor (Methylnaltrexone)
• Thomson Healthcare (via Mayo Clinic): Methylnaltrexone (Subcutaneous Route)
• Drugs.com: Relistor (Methyltrexone Bromide)
• NationMaster: Methylnaltrexone
• Medpage Today: Methylnaltrexone (Relistor) Provides Relief for Opioid-Induced Constipation (May 28, 2008)

5 Latest Headlines on Methylnaltrexone

• More Methylnaltrexone News from Topix

What is Methylnaltrexone?

• National Cancer Institute: Definition of Methylnaltrexone
• National electronic Library For Medicines (NeLM): Methylnaltrexone (Relistor)
• Wikipedia: Methylnaltrexone

What Are The Uses for Methylnaltrexone?

• RxList: Relistor (Methylnaltrexone) Uses
• The New England Journal of Medicine: Methylnaltrexone for Opioid-Induced Constipation in Advanced Illness
• Medscape: Methylnaltrexone May Improve Postoperative Ileus After Segmental Colectomy

What Are The Side Effects, Interactions and Precautions for Methylnaltrexone?

• RxList: Side Effects of Relistor (Methylnaltrexone)
• Thomson Healthcare (via Mayo Clinic): Methylnaltrexone Side Effects
• Limpinkott Williams & Wilkins (via NDHnow): Relistor Side Effects

What are the Alternatives to Methylnaltrexone?

• Organized Wisdom: Psyllium
• Organized Wisdom: Laxatives
• Organized Wisdom: Fiber for Constipation

What are the Holistic Alternatives to Methylnaltrexone?

• AltMD: Cascara Sagrada Herbal Remedies
• About.com: Natural Treatments for Constipation Treatment
• GrannyMed: Home Remedies for Constipation

Wisdom, Blogs and Message Boards about Methylnaltrexone

• The Wall Street Journal: Constipation Drug Approved for The Very Ill and Dying (April 25, 2008)
• WebMD: Relistor Miracle Relief - Constipation
• Science Blog: Drug Blocks Opioid Side Effects: Could Improve Palliative Care

Clinical Trials for Methylnaltrexone

• ClinicalTrials.gov: Methylnaltrexone Clinical Trials
• CenerWatch: Clinical Trial Listings for Methylnaltrexone

Abuse of Methylnaltrexone

• RxList: Overdose of Methylnaltrexone

Scientific and Medical Journal Articles on Methylnaltrexone

• JAMA: Methylnaltrexone Articles
• PubMed Central: Methylnaltrexone Article Listings
• Google Scholar: Articles on Methylnaltrexone

Related WisdomCards

• Constipation
• Constipation Causes
• New Drug to Ease Severe Constipation
• Yoga for Constipation
• Opioids
• Fecal Impaction
• Chronic Pain Medications
• Constipation In Elderly
• Fiber for Constipation

GuideWisdom and Fast Facts References

1. ↑ Mayo Clinic: Methylnaltrexone (Subcutaneous Route)
2. ↑ ^{2.0 2.1} Wikipedia: Methylnaltrexone

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