Major Depressive Disorder Causes WisdomCard

Our Guides and Physician Review team have organized the Top 10 Health Resources on Major Depressive Disorder Causes and compiled helpful research notes below.


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Research Notes on Major Depressive Disorder Causes


There is no exact cause of major depressive disorder, but there are many factors that contribute to it. Some evidence shows that people with major depression have physical changes in their brain. Other studies suggest that there is a genetic link that could cause major depression, but the exact genes that are affected are not known at this time. Situations can also lead to major depression, such as the loss of a loved one or prolonged stress.1

Fast Facts:

  • An imbalance in neurotransmitters can be a cause of major depression.2
  • Major depression is likely caused by more than one or two factors.3
  • Hormonal changes may contribute to major depression in women.3

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Research Notes References

  1. Mayo Clinic: Depression (Major Depression): Causes
  2. National Institute of Mental Health: What Causes Depression?
  3. 3.0 3.1 All About Depression: Causes of Depression

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  • Contributor: Misty Staker
  • Reviewer: Emily Lapkin
  • Supervised by: The OrganizedWisdom Physician Review Team
  • Redirects: Causes of Major Depressive Disorder, Causes of Depressive Disorder, Depressive Disorder Causes, Causes of Clinical Depression, MDD Causes, Causes of Major Depression, Cause of Major Depressive Disorder, Major Depressive Disorder Cause
  • Last update: Jul. 19, 2009

Each WisdomCard is handcrafted by our team of physician-guided health advocates. Our goal is to make it easy for you to find the most useful health resources for any health topic by filtering out spam and bad links.

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