Holoprosencephaly WisdomCard™

Our Guides and Physician Review team have organized the Top 10 Health Resources on Holoprosencephaly and compiled helpful research notes below.

  1. National Institute of Neurological Disorders and Stroke: Holoprosencephaly ninds.nih.gov - Holoprosencephaly
  2. Wikipedia: Holoprosencephaly en.wikipedia.org - Holoprosencephaly
  3. National Human Genome Research Institute: Learning About Holoprosencephaly genome.gov - Learning About Holoprosencephaly
  4. eMedicine: Holoprosencephaly emedicine.com - Holoprosencephaly
  5. Stanford University The Carter Centers: What is Holoprosencephaly? | Frequently Asked Questions stanford.edu - Frequently Asked Questions
  6. Gale Encyclopedia (via Healthline): Holoprosencephaly healthline.com - Holoprosencephaly
  7. National Organization for Rare Disorders: Holoprosencephaly rarediseases.org - Holoprosencephaly
  8. Neurology Channel: Holoprosencephaly neurologychannel.com - Holoprosencephaly
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Research Notes on Holoprosencephaly


Holoprosencephaly is a disorder caused by the failure of the prosencephalon (the embryonic forebrain) to sufficiently divide into the double lobes of the cerebral hemispheres. The result is a single-lobed brain structure and severe skull and facial defects. In most cases of holoprosencephaly, the malformations are so severe that babies die before birth. In less severe cases, babies are born with normal or near-normal brain development and facial deformities that may affect the eyes, nose, and upper lip.

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