Hay-Wells Syndrome WisdomCard

Our Guides and Physician Review team have organized the Top 10 Health Resources on Hay-Wells Syndrome and compiled helpful research notes below.


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Research Notes on Hay-Wells Syndrome


Hay-Wells syndrome is an extremely rare disorder. Hay-Wells syndrome is autosomal dominant, that is caused by a missense mutation in the S-Adenosyl methionine region of the TP73L (p63) gene.1 Characteristics of Hay-Wells syndrome include sparse, coarse, wiry hair, sparse eyelashes, excess bands of fibrous tissue that cause the edges of the upper and lower eyelids to fuse together; cleft palate and cleft lip.2

Fast Facts:

  • Also known as ankyloblepharon-ectodermal dysplasia-clefting syndrome (AEC syndrome).1
  • There are 150 types of ectodermal dysplasia disorders and Hay-Wells is one of the least known types.1
  • Ectodermal dysplasias typically affect the teeth, hair, nails and skin.2

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Research Notes References

  1. 1.0 1.1 1.2 Wikipedia: Hay-Wells Syndrome
  2. 2.0 2.1 WebMD: Hay-Wells Syndrome

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