Hand-Foot Syndrome WisdomCard

Our Guides and Physician Review team have organized the Top 10 Health Resources on Hand-Foot Syndrome and compiled helpful research notes below.


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Research Notes on Hand-Foot Syndrome


Hand-foot syndrome is a side effect of chemotherapy that causes a skin reaction that appears on the palms of the hands and/or the soles of the feet. Symptoms of hand-foot syndrome include tingling or numbness, swelling, redness, peeling skin, and tenderness or pain. Blistering can occur if there is no change in treatment.1

Fast Facts:

  • Hand-foot syndrome typically occurs within a few weeks of beginning chemotherapy, although it can appear at any time.1
  • Hand-foot syndrome can be treated by changing treatment, or taking acetaminophen (Tylenol) or ibuprofen, corticosteroids, and/or vitamin B6.2
  • Hand-foot syndrome may be prevented by changes in activities and clothing, drinking plenty of water, and avoiding caffeine.2

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Research Notes References

  1. 1.0 1.1 OncoLink: Patient Guide to Hand-Foot Syndrome
  2. 2.0 2.1 Melvin and Bren Simon Cancer Center: Hand-Foot Syndrome Information

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