Frequently Asked Questions

Depression 101: About Antidepressants

How do antidepressants help relieve depression?

Answered by:

Tanveer Padder, M.D.

Diplomate, American Board of Psychiatry and Neurology

Antidepressants help people with depression by making the body's natural chemicals more available to the brain. Most antidepressants are believed to work by slowing the removal of certain chemicals from the brain. These chemicals are called neurotransmitters (such as serotonin, norepinephrine and dopamine). Neurotransmitters are needed for normal brain function and are involved in the control of mood and in other responses and functions, such as eating, sleep, pain, and thinking. By restoring the brain's chemical balance, antidepressants help relieve the symptoms of depression.

Typically, antidepressants are taken for 4 to 6 months. In some cases, however, patients and their doctors may decide that antidepressants are needed for a longer time.

Generally, about two-thirds of depressed people will respond to any given antidepressant. People who do not respond to the first anti-depressant they have taken have an excellent chance of responding to another.

However, because some of these neurotransmitters (like norepinephrine) are contained in neural pathways in other parts of the brain and nervous system, some antidepressants can have side effects (like changes in blood pressure and saliva production). Also, because the pathways involved in major depressive disorder are in the lower brain and brain stem, antidepressants may interfere with other functions, like appetite, sleep and sexual function.

Dr. Padder is a diplomate of the American Board of Psychiatry and Neurology. He is currently medical director of two mental health clinics in Columbia, Maryland, and a consulting psychiatrist at Howard County General Hopsital, an affiliate of Johns Hopkins Medicine. Write to Dr. Padder at tanveerpadder@gmail.com.

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