Diethylstilbestrol WisdomCard™

Our Guides and Physician Review team have organized the Top 10 Health Resources on Diethylstilbestrol and compiled helpful research notes below.

  1. Wikipedia: Diethylstilbestrol en.wikipedia.org - Diethylstilbestrol
  2. American Family Physician (via American Academy of Family Physicians): Diethylstilbestrol Exposure (May 15, 2004)aafp.org - Diethylstilbestrol Exposure
  3. UHRad: Women's Diagnostic Imaging Teaching Files: Case Two - Diethylstilbestrol (DES) Exposure uhrad.com - Women's Diagnostic Imaging Teaching Files: Case Two - Diethylstilbestrol (DES) Exposure
  4. Center for Disease Control and Prevention: DES Update: Consumers cdc.gov - DES Update: Consumers
  5. National Cancer Institute: DES: Questions and Answers cancer.gov - DES: Questions and Answers
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Research Notes on Diethylstilbestrol


Diethylstilbestrol (DES) is an oral nonsteroidal estrogen that was first used in 1938. In 1941, it was given FDA approval in the treatment of vaginitis, monopausal symptoms and breast engorgement for postpartum lactating women.1 Later, the drug was used to treat various types of cancer and to prevent miscarriage.1 It was later discovered that women prescribed DES were at an increased risk of breast cancer, and the carcinogenic effect lasts for several generations.1

Fast Facts:

  • DES daughters have as much as a 2.5 fold increase in breast cancer after age 40.1
  • DES sons are at higher risks of genital abnormalities and infertility.2
  • Diethylstilbestrol is no longer in production.

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Research Notes References

  1. ↑ 1.0 1.1 1.2 1.3 Wikipedia: Diesthylstilbestrol
  2. ↑ Center for Disease Control and Prevention: Known Health Effects for DES Sons

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