Depakote and Insomnia WisdomCard

Our Guides and Physician Review team have organized the Top 10 Health Resources on Depakote and Insomnia and compiled helpful research notes below.


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Research Notes on Depakote and Insomnia


One of the side effects of taking Depakote (divalproex) is insomnia.1 Approximately 15 percent of those who use Depakote for seizures experience insomnia.2 Depakote was less common for those who take Depakote to treat other conditions.2 If insomnia becomes a problem for you, consult with your doctor for treatment options.

Fast Facts:

  • Depakote is used to treat bipolar disorder, migraines, and epilepsy.1
  • Avoid caffeine and alcohol at least six hours prior to bedtime if you are taking Depakote and have insomnia.2
  • If your insomnia persists, your doctor may recommend switching medications.

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Research Notes References

  1. 1.0 1.1 PDRHealth: Depakote: What Side Effects May Occur?
  2. 2.0 2.1 2.2 eMedTV: Depakote and Insomnia

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