Crigler-Najjar Syndrome

Research Notes on Crigler-Najjar Syndrome

Crigler-Najjar syndrome is caused by an abnormal gene. The gene fails to make a working enzyme (bilirubin glucuronyltransferase).This enzyme, in its normal (working ) form, is capable of converting bilirubin into a water-soluble (and therefore easily excreted) form. As a result, bilirubin can build up in the body, and can damage the brain and other organs.The syndrome is inherited as an autosomal recessive trait.Infants who inherit the trait from both parents (this is called being homozygous for the abnormal gene) develop severe jaundice (hyperbilirubinemia) beginning a few days after birth.Genetic counseling is recommended for prospective parents with a family history of Crigler-Najjar syndrome. People who carry the gene can be recognized by blood testing.

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5 Great Resources on Crigler-Najjar Syndrome

• Wikipedia: General Information About Crigler-Najjar Syndrome and The Different Types
• A.D.A.M (via MedlinePlus): Crigler-Najjar syndrome
• eMedicine: An Overview on Crigler-Najjar Syndrome
• Online Mendelian Inheritance in Man: Indepth Information on Crigler-Najjar Syndrome
• New York Times Health Guide: Crigler-Najjar Syndrome

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5 Latest Headlines on Crigler-Najjar Syndrome

• More Crigler-Najjar Syndrome News from Topix

What is Crigler-Najjar Syndrome?

• AHealthyMe: Crigler-Najjar syndrome
• A.D.A.M (via About.com): Information for Crigler-Najjar syndrome
• Orphanet: Summary of Crigler-Najjar syndrome

What Are The Symptoms of Crigler-Najjar Syndrome?

• BBC Health: Jaundice in Newborns
• New York Times Health Guide: http://health.nytimes.com/health/guides/disease/newborn-jaundice/overview.html Newborns with Jaundice
• WrongDiagnosis: Symptoms of Congenital hyperbilirubinemia (Crigler-Najjar syndrome, type 1)

What Are The Causes and Complications of Crigler-Najjar Syndrome?

• A.D.A.M (via Wake Forest University Baptist Medical Center: Crigler-Najjar Syndrome Complications
• Crigler-Najjar Association: Crigler-Najjar Syndrome is Caused by a Liver Enzyme Deficiency
• Marion Bessin Liver Research Center Inherited Disorders of Bilirubin Glucuronidation-A Cause of Crigler-Najjar Syndrome

What Are The Treatments and Medications for Crigler-Najjar Syndrome?

• Mayo Clinic: [http://www.mayoclinic.org/genetic-liver-diseases/crigler-najjar.html Treatment of Crigler-Najjar Syndrome
• HealthScout: Treatment
• TauMed: Crigler-Najjar Syndrome Treatment

What Are The Holistic and Alternative Treatments for Crigler-Najjar Syndrome?

What Are The Types, Stages and Survival Rates of Crigler-Najjar Syndrome?

• UpToDate: Types of Crigler-Najjar Syndrome
• Patient UK: Crigler-Najjar Syndrome Prognosis
• WrongDiagnosis: Prognosis of Neonatal Jaundice

How Do You Prevent Crigler-Najjar Syndrome?

• University of Maryland Medical Center: Crigler-Najjar syndrome Prevention
• Livestrong: Prevention
• WebHealthCentre: Jaundice Prevention

Wisdom, Blogs, and Message Boards about Crigler-Najjar Syndrome

Foundations and Support Groups on Crigler-Najjar Syndrome

• American Liver Foundation: Voices of Liver Disease
• P.I.C.K: Parents of Infants and Children with Kernicterus
• Crigler-Najjar Association: A Foundation That Focuses on Crigler-Najjar Syndrome

Scientific and Medical Journal Articles on Crigler-Najjar Syndrome

• Google Scholar: Recent Articles on Crigler-Najjar Syndrome
• PubMed: Journal Articles For the Last 5 Years for Crigler-Najjar Syndrome
• Nature: Crigler-Najjar Syndrome Journal Articles

Clinical Trials on Crigler-Najjar Syndrome

• ClinicalTrials.gov: Clinical Trials for Crigler-Najjar Syndrome

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