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GuideWisdom™

This WisdomCard managed by: Nicole Kinsey

Colon cancer is the third most common form of cancer in the United States. A small percentage of colon cancers are hereditary. Several genes and several different genetic conditions are associated with an increased risk of colorectal cancer.

Fast Facts:

• --Genetic conditions, such as familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC) predispose an individual to colon cancer.
• --There is an increased risk of colon cancer associated with multiple SNPs, including rs6983267, rs2273535, and rs7903146.
• --Early testing is advised for those with a family history of colon cancer.

5 Great Resources on Colon Cancer Genetics

• National Cancer Institute (NCI): Genetics of Colorectal Cancer
• American Society of Clinical Oncology: The Genetics of Colorectal Cancer
• Memorial Sloan-Kettering Cancer Center: Colon Cancer & Heredity
• Mid-Atlantic Cancer Genetics Network: Colon/Rectal Cancer
• University of Michigan Comprehensive Cancer Center: Colorectal Cancer Genetics

5 Latest Headlines on Colon Cancer Genetics

• More Colon Cancer Genetics News from Topix

What are the Genetic Diseases and Conditions Associated With Colon Cancer?

• NCI: Genetics of Colorectal Cancer: Major Genetic Syndromes
• MedicineNet: What about genetic testing for colon cancer?
• Genetic Health: Colon Cancer
• Genetics Home Reference: Colorectal Cancer

Genes and Mutations Associated with Colon Cancer?

• SNPedia: Colorectal Cancer
• International Journal of Cancer: Exploring SNP-SNP interactions and colon cancer risk using polymorphism interaction analysis.
• Nature Genetics: A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21.

Wisdom, Personal Experiences and Blogs on Colon Cancer Genetics

• Myriad: Personal Stories of Colon and Colorectal Related Cancer
• Men's & Drug's Health News Blog: Inherited Cancer Mutation Is Widespread In America (April 20, 2008)
• The Spittoon: SNPwatch: Large Studies Find New Associations for Colorectal Cancer and Type 2 Diabetes (March 31, 2008)
• Health Care Blog: What people are susceptible to colorectal cancer?
• CBS News: Quiz May Predict Genetic Colon Cancer (Sept. 26, 2006)
• University of Michigan Health System: U-M, Israeli scientists report major advance in search for genes associated with colon cancer (July 9, 2007)

Scientific and Medical Journals on Colon Cancer Genetics

• PubMed: Colon Cancer Genetics Articles
• JAMA: Colon Cancer Genetics Articles
• Google Scholar: Colon Cancer Genetics Articles
• British Journal of Cancer: National study of colorectal cancer genetics (Sept. 25, 2007)
• Annals of Internal Medicine: The Genetics of Colorectal Cancer (Oct. 2002)
• Nature Clinical Practice Gastroenterology & Hepatology: Genetic testing for colon cancer (Sept. 5, 2006)
• Cancer Epidemiology Biomarkers & Prevention: Colon Cancer Family Registry: An International Resource for Studies of the Genetic Epidemiology of Colon Cancer (Nov. 1, 2007)

Clinical Trials on Colon Cancer Genetics

• ClinicalTrials.gov: Familial Colon Cancer Trials
• Center Watch: Colon Cancer Trials
• The Cancer Genetics Network: Colon Cancer Sibling Pair Study
• National Genome Research Institute: Current NHGRI Clinical Studies

Related WisdomCards

• Colon Cancer
• Colon Polyps
• Familial Adenomatous Polyposis
• Hereditary Nonpolyposis Colorectal Cancer
• Attenuated Familial Adenomatous Polyposis
• Muir-Torre Syndrome
• Gardner Syndrome
• Turcot Syndrome
• MYH-Associated Polyposis
• Peutz-Jeghers Syndrome
• Juvenile Polyposis Syndrome
• rs6983267
• rs2273535
• rs7903146

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