CA-125 Testing WisdomCard

Our Guides and Physician Review team have organized the Top 10 Health Resources on CA-125 Testing and compiled helpful research notes below.


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Research Notes on CA-125 Testing


CA-125 is a cancer antigen, or a protein that is found on the surface of many ovarian cancer cells. CA-125 levels are often tested in those who have previously battled ovarian cancer as an increase in the level of CA-125 found in the blood can signal a recurrence of cancer. CA-125 testing is also performed as a way to measure the success of chemotherapy or other types of cancer treatments.1

Fast Facts:

  • Although CA-125 is typically measured via a blood test, fluid removed from the chest or abdomen may also be tested for CA-125.2
  • While CA-125 testing can be useful to help determine whether cancer has returned, the CA-125 test alone is not recommended for initial diagnosis.2
  • Conditions such as pregnancy, endometriosis, pancreatitis, pelvic inflammatory disease, and even menstruation can cause an elevated reading in CA-125 levels.2

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Research Notes References

  1. Healthwise (via WebMD): Cancer Antigen 125 (CA-125)
  2. 2.0 2.1 2.2 MedicineNet: CA 125

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