Burton Agammaglobulinemia

X-linked agammaglobulinemia (also called X-linked hypogammaglobulinemia, XLA, Bruton type agammaglobulinemia) is a rare X-linked genetic disorder that affects the body's ability to fight infection. XLA patients do not generate mature B cells. B cells are part of the immune system and normally manufacture antibodies which defends the body from infections. Patients with untreated XLA are prone to develop serious and even fatal infections. Patients typically present in early childhood with recurrent infections, particularly with extracellular, encapsulated bacteria. …read more from Wikipedia