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GuideWisdom™

This WisdomCard managed by: Nicole Kinsey

BRCA1 (breast cancer 1, early onset) is a gene in a class known as tumor suppressors. Variations in this gene have been found to correlate with an increased risk of breast cancer and other cancers, particularly ovarian cancer.

Fast Facts:

• -- Women with a family history of breast cancer have the option of having a BRCA Test that checks for variations in the genetic structure that can predispose them to breast cancer.
• -- BRCA1 and BRCA2 were the first breast cancer genes to be identified.
• -- Breast cancer genes can be passed from either mother or father.

5 Great Resources on BRCA1

• Genetics Home Reference: BRCA1
• Memorial Sloan-Kettering Cancer Center: Breast/Ovarian Cancer: BRCA1 & BRCA2
• Gene Reviews: BRCA1 and BRCA2 Hereditary Breast/Ovarian Cancer
• Wikipedia: BRCA1
• MedicineNet: Definition of BRCA1

5 Latest Headlines on BRCA1

• More BRCA1 News from Topix

What are the Diseases and Conditions Associated With BRCA1?

• MD Anderson Cancer Center: Hereditary Breast & Ovarian Cancer
• Genetic Health: How Are Breast and Ovarian Cancer Inherited?
• Stanford Cancer Center: Hereditary Breast Ovarian Cancer Syndrome (BRCA1 / BRCA2)
• Johns Hopkins Pathology: Molecular Basis of Hereditary Predisposition to Ovarian Cancer
• VCU Massey Cancer Center: Hereditary breast ovarian cancer syndrome

Genes and Mutations Associated With BRCA1?

• SNPedia: BRCA1
• National Cancer Institute (NCI): Genetics of Breast and Ovarian Cancer: Major Genes
• Genetics Home Reference: What genes are related to breast cancer?
• Online Mendelian Inheritance in Man: BRCA1

Testing for BRCA1

• NCI: Genetic Testing for BRCA1 and BRCA2: It's Your Choice
• American Cancer Society: Genetic Tests and Breast Cancer Risk: Not Perfect
• Genetic Health: Considering Genetic Testing
• Healthwise (via WebMD): Breast Cancer (BRCA) Gene Test

Wisdom, Blogs, and Message Boards about BRCA1

• HealthTalk: If I had only known I was a BRCA carrier sooner! | Living with BRCA breast cancer gene mutation
• Gene Sherpas: Jessica Queller and BRCA1 | Having a Breast Augmentation? Get tested for BRCA?
• Women's Bioethics Project: Testing positive for BRCA: then what?
• Ideas For Women: The paradox of BRCA1 in breast cancer
• Cancer Genetics: When Having BRCA Mutation Is Not So Bad or Even Better
• Genetics & Health: Breast cancer risk varies amongst BRCA gene carriers | 50% BRCA 1 genes have PTEN mutations | Male relatives of female BRCA carriers also at risk of developing prostate cancer
• Science Daily: Breast Cancer Risk Elevated In Male BRCA Mutation Carriers (Nov. 29, 2007)
• MySpace: BRCA1
• Our Bodies Ourselves: One Woman's Story with BRCA1

Scientific and Medical Journal Articles on BRCA1

• PubMed: BRCA1 Articles
• JAMA: BRCA1 Articles
• Google Scholar: Recent Articles on BRCA1
• Journal of the National Cancer Institute: Cancer Risk Estimates for BRCA1 Mutation Carriers Identified in a Risk Evaluation Program (Sept. 18, 2002)

Clinical Trials on BRCA1

• ClinicalTrials.gov: Studies on BRCA1
• CenterWatch: BRCA1 Clinical Trials

Related WisdomCards

• Breast Cancer
• Breast Cancer Genetics
• BRCA Test
• BRCA2
• Hereditary Breast Ovarian Cancer Syndrome
• Peutz-Jeghers Syndrome
• Cowden Syndrome
• Li-Fraumeni Syndrome
• Ataxia Telangiectasia

User Recommended Links for BRCA1

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