Antidepressants for Chronic Pain WisdomCard™

Our Guides and Physician Review team have organized the Top 10 Health Resources on Antidepressants for Chronic Pain and compiled helpful research notes below.

  1. Mayo Clinic: Antidepressants: Another weapon against chronic pain mayoclinic.com - Antidepressants: Another weapon against chronic pain
  2. Healthwise (via WebMD): Tricyclic antidepressants for chronic pain webmd.com - Tricyclic antidepressants for chronic pain
  3. Aetna InteliHealth: Antidepressants intelihealth.com - Antidepressants
  4. American Academy of Family Physician: Antidepressants and Antiepileptic Drugs for Chronic Non-Cancer Pain aafp.org - Antidepressants and Antiepileptic Drugs for Chronic Non-Cancer Pain
  5. American Pain Foundation: Antidepressants for Pain painfoundation.org - Antidepressants for Pain
  6. Wikipedia: Antidepressants and antiepileptic drugs en.wikipedia.org - Antidepressants and antiepileptic drugs
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Research Notes on Antidepressants for Chronic Pain


Antidepressants are one of the most commonly prescribed medications in the treatment of chronic pain. The tricyclic antidepressant is the drug choice for chronic pain because it neither causes addiction nor dependence. It is important to know that pain relief from antidepressant therapy can take several weeks to achieve the desired effect.

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