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GuideWisdom™

This WisdomCard managed by: Chris Miller

Alosetron (commonly referred to as Lotronex) is a medication intended for women with severe diarrhea-predominant irritable bowel syndrome (IBS). It's used to slow the movement of stools (bowel movements) through the intestines. Since it is known to cause serious side effects, a doctor needs to prescribe this drug. Common symptoms include: abdominal pain, cramping, bloating, and constipation.

Fast Facts:

• -- It's not intended for men with IBS.
• -- Other symptoms may include frequent bowel urgency and fecal incontinence.
• -- Discontinue the drug immediately if there are symptoms of constipation or ischemic colitis.
• -- Complications of a blocked, ruptured or damaged bowel may be caused by this medicine.

5 Great Resources on Alosetron

• International Foundation for Functional Gastrointestinal Disorders (IFFGD): Lotronex
• Lotronex: Official Site
• Micromedex (via Mayo Clinic): Alosetron (Oral Route)
• DrugDigest: Alosetron
• First DataBank (via WebMD): Alosetron Oral Warnings

5 Latest Headlines on Alosetron

• More Alosetron News from Topix

What is Alosetron?

• Cerner Multum (via Drugs.com): Lotronex (Alosetron)
• FDA/Center for Drug Evaluation and Research (CDER): Lotronex (Alosetron Hydrochloride) Drug Information: Questions and Answers
• RxList: Lotronex (Alosetron Hydrochloride) Tablets: Drug Description
• Wikipedia: Alosetron

What Are The Uses for Alosetron?

• MyIBDCentral: Alosetron (Lotronex) for IBS
• Healthwise (via Revolution Health): Alosetron (Lotronex) for Irritable Bowel Syndrome
• MedicineNet: Prescribed For the Treatment of Diarrhea-Predominant IBS
• National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): Using Alosetron for Treament of IBS
• UpToDate: Alosetron Hydrochloride (Lotronex) for Irritable Bowel Syndrome
• eMedicine: Alosetron: Antidiarrheal Agent

What Are The Side Effects, Interactions and Precautions for Alosetron?

• DrugDigest: Other Drugs That Interact With Alosetron
• Micromedex (via Mayo Clinic): Side Effects of Alosetron
• Cerner Multum (via HealthCare): Other Drugs that Affect Alosetron
• Patientsville: Lotronex Side Effects
• Wikipedia: Serious Adverse Effects of Alosetron

What are the Alternatives to Alosetron?

• American Academy of Family Physicians (AAFP): Medications for Treatment of Irritable Bowel Syndrome
• MedicineNet: Tegaserod (Zelnorm)...New Drug for Irritable Bowel Syndrome
• U.S. Food and Drug Administration: FDA Approves Amitiza for IBS-C

What are the Holistic Alternatives to Alosetron?

• Acupuncture.com: Irritable Bowel Syndrome
• GrannyMedMD: Home Remedies For Diarrhea
• HerbChina2000: Constipation

Wisdom, Blogs and Message Boards about Alosetron

• Drugs-Forum: Irritable Bowel Syndrome (IBS) Treatment
• HealthBoards: Alosetron a.k.a. Lotronex
• IBS Self Help and Support Group: Low-Dose Alosetron Controls IBS Symptoms With Minimal Increases in Constipation
• IBS Support Group: Just Wanting To Find Out More...

Clinical Trials for Alosetron

• CenterWatch: Alosetron Clinical Trials
• ClinicalTrials.gov: Alosetron Case Study Clinical Trials

Controversy and Lawsuits about Alosetron

• About.com: The Lotronex Wars: Is it safe, or isn't it?
• CNN.com: FDA Re-Examines Lotronex After Death Reports (Oct. 31, 2000)
• GlaxoSmithKline (GSK): Lotronex® Tablets to be Re-Introduced for Women with Severe Diarrhea-Predominant IBS
• Medscape: Alosetron (Lotronex) Associated Rarely With Serious Gastrointestinal Adverse Events
• U.S. Food and Drug Administration: Grappling With the Quality of Life: Patients, FDA and Drug Companies Struggle to Link Therapies With Well-Being

Abuse of Alosetron

• Cerner Multum (via HealthCare): Overdose of Alosetron
• DrugLib: Lotronex (Alosetron Hydrochloride) - Overdosage and Contraindications
• Pharma-Help: Lotronex Overdose

Scientific and Medical Journal Articles on Alosetron

• Annals of Internal Medicine: Alosetron Journal Articles
• JAMA: Alosetron Archived Journal Articles
• PubMed Central: Alosetron Archived Articles

Related WisdomCards

• Balanced Diets for IBD
• Diarrhea
• Diarrhea Remedies
• Digestive Health
• Foods to Help Stop Diarrhea
• IBS Awareness Month
• IBS Support Groups
• Irritable Bowel Syndrome
• Ischemic Colitis

User Recommended Links for Alosetron

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