Acute Promyelocytic Leukemia WisdomCard™
Our Guides and Physician Review team have organized the Top 10 Health Resources on Acute Promyelocytic Leukemia and compiled helpful research notes below.
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Research Notes on Acute Promyelocytic Leukemia
Acute promyelocytic leukemia (APL) is a cancer of the blood and bone marrow and is a subtype of acute myelogenous leukemia (AML). With APL, there is an abnormal accumulation of immature granulocytes called promyelocytes. Signs and symptoms of APL include fever, fatigue, weight loss or a loss in appetite, shortness of breath with exertion, anemia, unusual bruising or bleeding, persistent infections and bone pain or joint pain.1
Fast Facts:
- APL was first recognized as a distinct disease in 1957.2
- The treatment for APL is unique; most patients are treated with all-trans-retinoic acid (ATRA) in combination with chemotherapy. ATRA is a form of differential therapy that activates the retinoid receptor RAR and causes promyelocytes to mature, which deters them from proliferating.2
- 75-80 percent of patients are expected to be long term survivors with the treatment of APL using the combination of chemotherapy and ATRA.3
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Research Notes References
- ↑ Wikipedia: Acute Promyelocytic Leukemia
- ↑ 2.0 2.1 MedicineNet: Acute Promyelocytic Leukemia Definition
- ↑ St.Jude Childrens Research: Acute Promyelocytic Leukemia
About this WisdomCard
- Contributor: Amy Sandhu
- Reviewer: Scott Pearlman, M.D.
- Supervised by: The OrganizedWisdom Physician Review Team
- Last update: Nov. 12, 2009
Each WisdomCard is handcrafted by our team of physician-guided health advocates. Our goal is to make it easy for you to find the most useful health resources for any health topic. In addition to filtering out spam and bad links, WisdomCards highlight tips and warnings, such as:
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About WisdomCard
Meet our contributors and reviewers
- Contributor: Amy Sandhu
- Reviewer: Scott Pearlman, M.D.
- Supervised by: The OrganizedWisdom Physician Review Team
- Redirects: APL, Promyelocytic Leukemia, APL treatment, Acute promyelocytic leukemia survival rates, Acute promyelocytic leukemia treatments
- Last update: Nov. 12, 2009
Each WisdomCard is handcrafted by our team of physician-guided health advocates. Our goal is to make it easy for you to find the most useful health resources for any health topic by filtering out spam and bad links.
